Unfortunately Emma Watson has flat out denied she is interested in the role of Anastasia Steele in the film adaptation of Fifty Shades of Grey.
… but it looks like Angelina Jolie could be interested.
“Angelina kept hearing about the book while she was in the UK. All the girls on set were talking about it and how it’s being made into a film. Angelina went out and bought herself a copy, thinking she’d love a part in the hot topic on everyone’s lips at the moment. She knows the film is bound to be a huge hit.”