Diabetes Mellitus: Beta Cell Glucose Tipping Point Discovered – StudyAccording to the American Diabetes Association, 8.3 percent of the U.S. population has diabetes. The disease can lead to nerve loss, blindness and death.
In a study published recently in the journal PLOS ONE, researchers from Sanford-Burnham and UC Santa Barbara have concluded that changes in cellular metabolism play a bigger role in the development of type 2 diabetes than previously thought, perhaps an even larger part than genetic predisposition plays in the disease.
The research team, including Jamey Marth, Ph.D., developed a computational model to better understand the underlying causes and progression of type 2 diabetes. The model revealed a metabolic “tipping point” that, when crossed, prevents the pancreas from adequately sensing blood sugar and secreting insulin. The team expects the discovery will form the basis for new efforts to prevent and treat type 2 diabetes.
Type 2 diabetes
Type 2 diabetes is a chronic condition in which blood sugar (glucose) levels are high. Normally, beta cells in the pancreas continually “sample” the bloodstream to keep tabs on glucose levels. When they sense a rise in blood glucose (such as after a meal), beta cells secrete insulin to keep levels from getting too high. But in type 2 diabetes, beta cells fail to execute this important function. As a result, blood glucose levels rise, wreaking havoc on blood vessels and other organ systems.
Obesity has long been linked to type 2 diabetes, but the cellular origin of the disease due to beta cell failure has not been described until now. “In obesity, there’s also a lot of fat in the system,” said Marth. “When beta cells are exposed to high levels of fat, their glucose transport mechanism breaks down. That’s how the environment plays a role, even among large segments of the population who are genetically ‘normal.’” Marth is a professor at Sanford-Burnham and UC Santa Barbara, where he holds the John Carbon Chair in Biochemistry and Molecular Biology and the Duncan and Suzanne Mellichamp Chair in Systems Biology.
Simulating glucose transport
In this latest study, Marth and colleagues developed a mathematical model to track how beta cells take up, or sample, glucose in the bloodstream. The model uses data from normal and diabetic donors, as well as supporting information from rodent studies.
The model revealed a glucose “tipping point.” In a healthy person, beta cells take in enough glucose to stay above the threshold. In type 2 diabetics, however, the amount of glucose transported into beta cells drops below the tipping point. That’s why the cells don’t properly sense glucose or secrete appropriate amounts of insulin.
Toward new therapies
This model also revealed steps along the glucose transport system where therapeutic intervention might help.
“We’re trying to understand what actually causes disease, which is defined as cellular dysfunction. Once we understand what causes disease we can make a difference by devising more rational and effective preventative and therapeutic approaches,” Marth said.
Any new discovery with respect to Diabetes Mellitus would be received by Doctors and Diabetics with great fanfare, and figuring out the Glucose Tipping Point for diabetics would be a very popular advancement.
Article by Dr.Heather Buschman, Ph.D.
Dr. Buschman, Ph.D., is a Research Associate at the Sanford-Burnham Medical Research Institute.