Alzheimer’s Disease New Drug to Prevent Dementia

A new type of drug may be the answer to treat and prevent Alzheimer’s disease, the most common dementia related illness.

Pharmaceutical companies in the United States and abroad have developed methods to fund  the Alzheimer’s disease research. They are competing to find ways to slow the progression of the disease which will affect 65 million people by 2030. Latest research showed promising prospects, which brought hopes to millions of Alzheimer’s patients.

Novartis AG plans to ramp up the research for the neurodegenerative disease. Novartis sells Exelon, a drug that breaks down a substance linked to memory and learning to lessen symptoms. It is also used in Parkinson’s disease. Novartis bought an Alzheimer’s vaccine in 2003 from Cytos Biotechnology AG, and complete the mid-stage trial in December.

Novartis is now racing to catch up with New Brunswick Merck and Co. and Roche Holding AG, which are conducting human tests for Alzheimer’s treatment. These pharmaceutical companies are trying to find a solution to slow the disease, but none could deliver, including Baxter International, which released Gammagard this month.

Strides to Combat Alzheimer’s

Prime Minister David Cameroon of UK urged clinicians and scientists to work together to improve treatments and find scientific breakthroughs to address one of the biggest social and healthcare challenges.

Christian Pike and his team from UC Davis School of Gerontology, spearheaded the study on the effects of TSPO ligands on male mice genetically engineered to develop Alzheimer disease. The TSPO ligand’s purpose is to increase the production of steroid hormones.

Davis made sure that the test subjects maintain low testosterone levels and other related hormones by castrating the younger mice, before the treatment while in older mice, the decrease developed as a normal consequence of aging.  Pike is looking at the effect of TSPO when the disease is at an early stage, and in older mice when the disease is much more severe. TSPO ligands showed significant improvement on the pathology of the disease and behavior of both ages.

Pike discovered surprising results on older mice who were treated one per week over four weeks. The findings suggested that TSPO ligands could significantly reverse the components of Alzheimer’s disease and have a great potential for use in treatment. Newer ligands are now in test phase for development of treatment for symptoms such as anxiety and other concurrent conditions. Pike stresses that there is a strong possibility that TSPO ligands use in the study can be evaluated for therapeutic efficacy in Alzheimer’s patients within the subsequent years.

More Developments in Research

The University of Oxford study suggests that elderly people could prevent Alzheimer’s disease by taking Vitamin B complex supplements, which have been found to reduce brain shrinkage by 90 percent. Folic acid, Vitamins B12 and B6 can reduce the level of homocysteine, which is a protein component that has a direct link to brain shrinkage in Alzheimer’s disease and similar conditions.

Patients with mild cognitive impairment showed better improvement by 50 percent if they take the supplements. This study is published in the Proceedings of the National Academy of Science. Dr David Smith of the National Academy of Science told Daily Telegraph that the atrophy of the specific brain regions may be modified by simple and safe intervention. He adds that keeping the body and brain healthy as we get older is vital and cautioned against drawing conclusions from the early study results.

Another development in research was published yesterday in the Proceedings of the National Academy in Science. Researchers at the Cambridge’s Chemistry Department have identified the molecular trigger for Alzheimer’s disease. A highly toxic chemical called beta-amyloid, which exists in the brains of Alzheimer’s patients, has been found to increase the toxicity of other beta-amyloids.

The toxic protein molecule can be a possible trigger to the development of Alzheimer. The toxin can spread to the entire brain and eventually destroys it. This discovery will allow the specialists to carry out early treatment and diagnosis.

Written by: Janet Grace Ortigas

7 Responses to "Alzheimer’s Disease New Drug to Prevent Dementia"

  1. Lane Simonian   August 5, 2013 at 7:38 am

    Depending on other risk factors, Alzheimer’s disease can be prevented or delayed with a diet high in Omega 3 fatty acids (such as fish oil without mercury and phenols in various spices, fruits, and vegetables).

    http://alzheimer.neurology.ucla.edu/pubs/ColePreventionNBA2005.pdf

    This type of diet inhibits the formation of peroxynitrites which are the principal cause of Alzheimer’s disease. Through oxidation and nitration, peroxynitrites inhibit the biosynthesis and release of neurotransmitters involved in short-term memory (acetylcholine), sleep (melatonin), mood (serotonin), social recognition (oxytocin), and alertness (dopamine). Peroxynitrites prevent the regeneration of neurons in the hippocampus and cause the death of neurons.

    Methoxyphenols such as eugenol in rosemary essential oil, ferulic acid and eugenol in lemon balm [Melissa officinalis] essential oil, and ferulic acid, syringic acid, and vanillic acid scavenge peroxynitrites and reverse part of their damage. In the process, they improve cognition in Alzheimer’s patients. Ferulic acid also improves behavior in dementia patients, including those with Alzheimer’s disease. Before making any disparaging comments (and I get lots of them) please read the studies.

    http://onlinelibrary.wiley.com/doi/10.1111/j.1479-8301.2009.00299.x/abstract

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1738567/

    http://www.ncbi.nlm.nih.gov/pubmed/22780999

    http://www.ncbi.nlm.nih.gov/pubmed/21272180

    Reply
  2. PT10981   May 23, 2013 at 10:09 am

    You sure can: return to eating real food, high in saturated fats! The brain needs lots of saturated fat. This is why coconut oil works to reverse dementia. Eliminate all agricultural carbs (even oats); eliminate all sugar and all fruits; eliminate artificial fats (canola, soy, corn and other chemical-processed oils). Count carbs and keep them below 50g per day. Eat three cups of greens; three cups of sulfurs (onions, mushrooms, etc) and three cups of colored vegetables (except starchy ones like carrots) every day. If the vegetable grows above the ground it is good; below the ground it is likely has too many carbs. Take targeted multi-vitamins: D-E-A-K and especially K2. Also take methyl forms of B12 and Folic acid. This will reverse all forms of dementia

    Reply
    • Trollskiller   May 23, 2013 at 1:15 pm

      You can’t treat alzheimer’s with a diet, it’s a disease. You can’t treat diseases with a diet change. Obvious troll is obvious.

      Reply
      • PT10981   May 23, 2013 at 3:45 pm

        So what a person eats has no affect on their health outcome??? I am in my mid 50’s. After 2 years of doctors visits, MRIs, etc., I refused to take their drugs for the treatment of Parkinson’s and decided to change my diet from mostly sugar and carbs (I was indeed addicted) and I am now 98% healed…and I feel 30 years younger. What will grow to yield better fruit? a tomato planted in a chemical wasteland or if planted in good rich soil with minerals? That is the difference between processed foods and natural foods….the paleo people are right! Not a troll – I am convinced by my own personal journey and experience. The body will heal itself if you give it the correct micro and macro nutrients. BTW: I am Keto-adapted (less than 25g of carbs a day) and not looking back!

        Reply
        • Melvin Tan   November 25, 2013 at 4:35 am

          Hi,
          Can you please give a detail food and vitamin plans that can reverse dementia? I really need help,it seems nothing in this world could help..

          Reply
  3. Allansmith   May 22, 2013 at 8:25 am

    Researchers in Europe and S.America showed that a special combination of natural ingredients was reversing dementia and Alzheimer’s in even late stages. It worked..but when the drug makers found out that all the ingredients were natural and they could not profit off the diet they dropped the researchers. The diet was still online in many countries, it worked and was published, you can reverse this illness
    j
    ust google “MAL ALZHEIMER”

    Reply
    • Trollskiller   May 23, 2013 at 1:12 pm

      You can’t treat alzheimer’s with a diet, it’s a disease. You can’t treat diseases with a diet change. Obvious troll is obvious.

      Reply

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