Disease of Connective Tissue and Myofascial Pain [Video]

Disease

A girl has been reported recently in the obituary pages from complications of a disease. The specific complications are unknown, but donations for Ehlers-Danlos Syndrome (EDS) research have been requested. EDS is a connective tissue disease that causes many symptoms including myofascial pain. The sources have further requested to remain anonymous, but there was a case in late 2011 regarding EDS that warrants review.

A lawsuit against the company of Monster energy drink was pursued, though the company claimed their drinks had less caffeine than a cup of Starbucks coffee, the plaintiff attorneys allege the cardiac arrhythmia in Anais Fournier was suddenly brought on in response to the consumption of the energy drink. The autopsy report concluded that Fournier died of cardiac arrhythmia caused by caffeine toxicity, which complicated a preexisting mitral valve heart condition in association of Ehlers-Danlos syndrome. The Food and Drug Administration records held at the time that 18 deaths and 150 injuries were documented in connection with several brands of energy drinks since 2004.

Doctor Clair A. Francomano of Harvey Institute for Human Genetics speaks on the present research for EDS and hypermobility syndrome.

Collagen abnormalities (and joint laxity) make it hard for ligaments to hold the skeletal system up properly, so the muscles take over, causing muscle spasms, myofascial pain, and neuropathic pain. Degenerative disk disease, which is common in the aged population, can be found frequently in the teenage population with this syndrome. The most common forms of this disorder include the classical type I,II, and the hypermobile type III. Multisystem presentation of hypermobility syndrome consists of the musculoskeletal, dermatological, neurological, cardiovascular, gastrointestinal, and immunological systems. Because EDS has only been regarded as a “flexibility trait,” or just the myofascial element of a connective tissue disease,  the dangers of EDS and hypermobiilty syndrome have been overlooked.

“There is a reason sleep deprivation is used as torture,” Dr. Francomano says. People seen with these conditions have very “deranged” sleep cycles and rarely achieve adequate restorative sleep. Dr. Francomano mentions how often reports from sleep study centers do not fully address the questions patients and clinicians have, but rather conclude whether or not there is simply a form of apnea. Sleep architecture is the model of sleep cycles, Dr. Francomano says, and it is this model one must use in determining the quality of sleep a person is obtaining.

Multiple System Signs

  • Common musculoskeletal conditions and indicators of EDS, or hypermobility syndrome, include joint hypermobility, joint subluxations and dislocations, tendon and ligament rupture, stress fractures, degenerative disc disease, meniscus tears, chronic pain syndrome and myofascial pain.
  • Dermatological signs of the skin include soft, stretchy, translucent, easy bruising, and/or atrophic scarring.
  • Neurological signs include headaches, migraines, spondylolisthesis, craniocervical instability, cervical instability, Chiari I malformation, low-lying cerebellar tonsils, increased intracranial pressure, and cerebral spinal fluid (CSF) leaks. Problems with balance were also noted as a common symptom.
  • Cardiovascular conditions include mitral valve prolapse, aortic root dilation, aneurysms (for the vascular type of EDS), venous insufficiency, and fibromuscular dysplasia.
  • Gastrointestinal pain can be caused by dysmotility, esophageal spasm, gastro-esophageal reflux, constipation, Irritable Bowel Syndrome (IBS), sphincter of Oddi dysfunction, abdominal wall hernias.
  • A large number of patients report nausea, numbness, anxiety/severe panic attacks, depression, and insomnia. A small percentage are found to demonstrate seizures, and remarkably, normal Electroencephalography (EEG) readings. The EEG records electrical activity along the scalp and is mainly used to diagnose and manage epilepsy.
  • Immunologic symptoms include immunodeficiency, multiple allergies, and the medically fascinating mast cell activation disorder.
  • Autonomic dysfunction seen in patients with the hypermobility syndrome include postural orthostatic tachycardia syndrome,  where the change from a lying position to an upright position causes an abnormally large increase in heart rate. Sleep disturbances, and difficulty with temperature regulation have also been found.

Initial questioning a doctor may use in determining if further investigation is required often include questions like, “does the patient or have they ever been able to place their hands on the floor by bending forward with knees straight?” “Can the patient now or ever bend their thumb to touch their forearm?” “As a child, did the patient amuse his or her friends with body contortion of any kind?” “As a child or young adult, did the patient’s shoulder or knee cap dislocate during multiple accidents?” “Does the patient consider his or herself to be double-jointed?” Further studies will be necessary to determine why some individuals are able to live pain-free with hypermobility, and why others show signs of connective tissue disease or hypermobility syndrome with elements such as myofascial pain.

Dr. Francomano TCAPP Think Tank 2013 – NEW

By Lindsey Alexander

Sources:
Chronic Pain Partners
Weebly
Foundations for Excellence 

4 Responses to "Disease of Connective Tissue and Myofascial Pain [Video]"

  1. Kelly Cole   March 4, 2014 at 2:53 pm

    Hello my name is Kelly and I have an 8 year old son that started having migraines and hot flashes daily. Through an m.r.I. they found he had cerebellar tonsils but gave us very little information on this. If anyone can help us it would be greatly appreciated. When trying to research this condition, this page is the only thing that showed up. Thank you.

    Reply
    • hollyhaygood   April 14, 2014 at 12:15 pm

      The tonsils are part of the brain. They can herniate with a condition called Chiari malformation. I know people who had a tethered cord pulling the brain down into the spinal canal. I also know people who had a small skull and was compressing the brain. Chiari is often disregarded by the medical community. It can be fatal or it can be lived with for a long time. MRIs are not good representations of this part of the brain. Search for chiari eds experts and make sure your son is taken care of. Look up chiari syringomyelia foundation and the chiari institute in New York. This is all I know.

      Reply
  2. Paula Clarke   February 26, 2014 at 4:30 am

    Hi, I’m female & 40 years old & I have joint HMS, I have 70+ dislocations a day, I have sinus tachycardia, degeneration of the lower lumbar & degenerative discs, I have Spanning Ilio Band syndrome, osteoarthritis, muscle rigidity, muscular hernia in lower abdomen, chronic fatigue syndrome, chronic pain syndrome, polycystic ovaries, Fowlers Syndrome, complex regional pain syndrome, multiple drug and food allergies & I recently had to have a hysterectomy due to a womb prolapse, I can only walk a few steps with crunches, so I have to use a wheelchair. Are any of these conditions related to joint HMS?

    Thank you.

    Reply
    • Lindsey Alexander   February 26, 2014 at 12:31 pm

      I am not an expert, but from what I researched, some of those symptoms are related to EDS or HMS but some have not been documented, either because they aren’t related or have yet to be studied. That sounds a lot worse than the people I talked to with severe EDS. I think you need to contact the experts. Perhaps you can ask for recommendations of doctors near you. You can also search for Arnold Chiari experts because often times they also deal with EDS and HMS.

      Dr. Clair A. Francomano, MD
      6701 N Charles St #4105 Towson, MD 21204
      (410) 821-8444

      Reply

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