Breast Cancer Gene Now Linked to Uterine Tumor, New Study Shows

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A new study shows that breast cancer gene is now linked to a deadly uterine tumor although women resort to removing their ovaries in order to lower the main cancer risks. The research was discussed Monday at the annual meeting of the Society of Gynecologic Oncology in Tampa, Florida and Doctor Noah Kauff from Memorial Sloan Kettering Cancer Center in New York, the one who linked the evidence between breast and uterine cancer stated that, even if there is not enough evidence to make a change in the current practice, the findings kick off a series of studies made by specialists in women’s cancers.

Although it was believed that once the ovaries are removed, the risk of developing uterine cancer also decreases, a new study shows that breast cancer gene called BRCA1 is now linked to a deadly uterine tumor. As a result, women who carry BRCA1 genes and consider having their ovaries and fallopian tubes removed should discuss with their doctor about the possibility of removing the uterus, as well. According to Doctor Noah Kauff, the author of the research, out of 525 women with BRCA1 and BRCA2 mutations who did not undergo a hysterectomy in order to prevent the development of both uterine and breast cancer, four of the 296 female patients with BRCA1 who did not have their uterus removed developed the rare, yet deadly uterine tumor. Doctor Kauff stated that one case might be a coincidence, but “two all of a sudden raises eyebrows.” The study also concluded that the rate of the cases of violent uterine tumor years after the ovaries have been preventively removed is 26 times higher than previously expected.

Doctor Karen Lu, a specialist in women’s cancer at the largest cancer center in the United States, namely MD Anderson Cancer Center in Houston stated that she plans to study similar patients to see whether the new sresearch which shows that breast cancer gene BRCA1 is now linked to a deadly uterine tumor is correct. Although she mentioned that it is still early to recommend patients to resort to hysterectomy, she does admit that “it’s important for women to have that information.”

breast cancerStill, even if a woman decides to have a hysterectomy in order to decrease the chances of developing uterine cancer, factors like age and prior cancer history should be taken into consideration. The gene BRCA1 as well as BRCA2 were known to carry mutations that put women in danger of developing both ovarian and breast cancer, but a link to uterine tumor is a premiere. The National Cancer Institute notes that both mutations can be inherited from a person’s mother or father and the children of the parent carrying BRCA1 or BRCA2 have 50 percent chances of inheriting the mutation. The NCI also mentions that 12 percent of women develop breast cancer, while 55 to 65 percent of those who inherit BRCA1 are at risk and 45 percent of those with BRCA2 will have this illness.

For women with faulty genes, doctors advise screening often and early and recommend them to have their ovaries removed, especially since ovarian hormones also affect breast tumors. Although further research is needed in order to conclude whether breast cancer gene BRCA1 is genuinely linked to uterine tumor, a new study now states that they are connected. Angelina Jolie underwent preventive surgery to remove both breasts because of the faulty gene BRCA1, and she admitted that she plans on going through a second medical procedure to have her ovaries removed.

By Gabriela Motroc

Sources

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