Aging Successfully Reversed in Mice; Human Trials to Begin Next


Scientists have successfully reversed the aging process in mice according to a new study just released. Human trials are to begin next, possibly before the year is over. The study was published in the peer reviewed science journal Cell after researchers from both the U.S and Australia made the breakthrough discovery. Lead researcher David Sinclair of the University of New South Wales says he is hopeful that the outcome can be reproduced in human trials. A successful result in people would mean not just a slowing down of aging but a measurable reversal.

The study showed that after administering a certain compound to the mice, muscle degeneration and diseases caused by aging were reversed. Sinclair says the study results exceeded his expectations, explaining:

I’ve been studying aging at the molecular level now for nearly 20 years and I didn’t think I’d see a day when ageing could be reversed. I thought we’d be lucky to slow it down a little bit. The mice had more energy, their muscles were as though they’d be exercising and it was able to mimic the benefits of diet and exercise just within a week. We think that should be able to keep people healthier for longer and keep them from getting diseases of ageing.

The compound the mice ate resulted in their muscles becoming very toned, as if they’d been exercising. Inflammation, a key factor in many disease processes, was drastically reduced. Insulin resistance also declined dramatically and the mice had much more energy overall. Researchers say that what happened to the mice could be compared to a 60 year old person suddenly having the muscle tone and energy of someone in his or her 20s.

What’s more, say the researchers, these stunning results were realized within just one week’s time. The compound raises the level of a naturally occurring substance in the human body called nicotinamide adenine dinucleotide. This substance decreases as people age, although those who follow a healthy diet and get plenty of exercise do not suffer the same level of reduction in the substance as do people who do not exercise. This may explain why people who remain fit into their senior years often enjoy better health than others.

Scientists who participated in the study say that poor communication between mitochondria and the cell nucleus is to blame for the aging process. The compound the researchers have developed cause the cells to be able to “talk” to each other again. They compared the relationship between the nucleus and the mitochondria to a married couple; by the time the couple has been married for 20 years, “communication breaks down” and they don’t talk to each other as much. Just like a marriage, this relationship and communication within it can be repaired, say the researchers.

Aging has successfully been reversed in mice, but Sinclair says he needs to raise more money before he can commit to a date when trials may begin in humans. The results of this initial study in mice are very promising and may pave the way for similar results in humans.

By: Rebecca Savastio


ABC News

Science Direct

Huffington Post

75 Responses to "Aging Successfully Reversed in Mice; Human Trials to Begin Next"

  1. Jim page   August 30, 2015 at 2:20 pm

    Where do I sign?

  2. helga   March 12, 2015 at 1:00 pm

    I’d like to see more emphasis on NAD+ being utilized medically for tissue rejuvenation on patients effected with autoimmune and other illnesses.

  3. mike   December 20, 2014 at 10:13 pm

    I’ve no doubt a lot of people would say no, preferring to age naturally. I’d take it and reject aging.

  4. Tony Wallace   November 5, 2014 at 11:36 am

    Life Extension Magazine Nov ’14 has an article on NAD+’s DNA repair mechanism. Indicates studies on this started in 2001.

  5. Marti   November 5, 2014 at 10:47 am

    If it really worked for humans, we’d be looking at a serious overcrowding problem
    in the future.

  6. Bob   November 5, 2014 at 8:17 am

    “Just” regaining the muscle tone of a 30-year-old would be fantastic when you’re in your 70’s — even when you’re otherwise healthy and in good shape for your age. Getting up the hill from the supermarket, reducing the risk of falling and being able to get up if you do, seeing the better toned body in the mirror would all greatly improve ones quality of life.

  7. tepes   November 4, 2014 at 1:44 pm

    it will be expensive as hell , and only for the elite !

  8. CaitSidhe   April 5, 2014 at 8:09 pm

    *cough*Resident Evil*cough*

  9. gayle63   April 4, 2014 at 7:25 am

    I have heard of this study before, but I wonder if it would also reverse degenerative disease, especially brain degeneration (dementia, Alzheimer’s etc.). Just having toned muscle alone isn’t reversing ageing. What about bone health, heart health (although I suppose that is a muscle). Very, very interesting, but I suspect that this, like the Draco antiviral that popped up a few years ago, will mysteriously vanish from the radar.

    • DMT-07   November 5, 2014 at 10:46 am

      Muscle regeneration is just the proof-of-concept, probably selected by the researchers because performance deltas are easily measured. How do you tell that someone’s spleen is working better? More expensive testing. But even an undergrad can measure how long it takes a mouse to climb a vertical maze (a task both physically and cognitively challenging).
      As for expensive…sure, the wealthy will get it first, but they got DNA sequencing first (circa 2006, I believe.) But now you don’t have to pay US$300,000 for it…eight years later, it’s now under US$1000. Sure it’s nice when you can sell products to the people who buy cars that cost more than houses, but it’s the “bottom of the pyramid” where you can make billions…because your Total Addressable Market is vast.
      The future is here…it’s just not evenly distributed. So live as healthy a lifestyle as you can now…and live long enough to reach “escape velocity.”


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