Ebola Vaccine Potential in Turmeric Curcumin

ebola

Recent scientific research studies confirm the potential of turmeric curcumin as a vaccine for Ebola virus disease. A review of the studies was published in the International Journal of Experimental and Clinical Pathophysiology and Drug Research in February 2015.

The outbreak of Ebola in several neighboring countries in West Africa is fueling fears the virus could spread across continents. The apprehension is a bleak reminder of how epidemics in the past decimated populations in Europe and thought to have annihilated entire civilizations in the ancient world. The World Health Organization (WHO) reveals that the Ebola virus disease is progressing faster than efforts to contain it. Director General Margaret Chan says the organization is facing unprecedented challenges.

Turmeric curcumin ranks among the top herbal strategies for use in Ebola patients owing to its antioxidant and anti-inflammatory properties affirmed in more than 3,000 studies. The compound is credited with positive results on in-vitro and animal studies. Turmeric curcumin is a quintessential Asian spice (Cucuma Longa) that flavors many dishes and curcumin are the active curcuminoid substance with a therapeutic outcome. The substance can be ordered online.

Containment of Ebola

The customary countermeasures in the spate of disease outbreaks are to administer drugs, isolate the victims, and immunize affected local communities. Nonessential travel to the area is forbidden and continuing hunt for potentially infected persons. These steps are expected to slow down or control the disease and prevent transmission of the virus to others. However, the virus raises a different scenario.

There is no existing licensed pharmaceutical vaccine for this disease. Experimental vaccines are scheduled for early trials. The Ebola virus poses a fretful challenge in formulating vaccines that can mount a powerful immune response. The virus attacks in multiple forms requiring a broad immune response. Ebola’s lethal flair to propagate rapidly allows the virus to just as quickly stage a resistance to the drug.

Natural defense against Ebola

Current drugs doctors use on Ebola patients act merely as supportive therapy, meaning the agents on reinforce the patient’s immune system to fight the infection. Patients undergo oxygen therapy or blood or platelet transfusions are support modalities.

Turmeric curcumin is a natural substance which boosts the body’s immune system. It modulates over 100 genetic pathways and supports endocrinal, gastrointestinal and cardiovascular functions of the body. Some rare trials performed on human have shown less toxicity and no known side effects at a dosage of 12 g per day.

Cytokine Storm

According to the review, turmeric curcumin acts to suppress massive production of cytokines in the immune system. Cytokines are proteins crucial in cell signaling, and release of cytokines that influences the actions of other cells. A cytokine release is initiated by infections and other stimuli and when overproduction of proteins occurs, it is known as cytokine storm. Fatalities in patients infected with Ebola virus disease are partly due to cytokine storm occurring in the terminal stage of the infection.

Turmeric curcumin also has the power to regulate the release of cytokines IL6 (rheumatoid synovial fibroblasts), IL8 (human esophageal epithelial cells), TNFα (tumor necrosis factor-α), and others. A cytokine storm by any of these cytokines can overwhelm the immune system and cause hemorrhage, hypotension and organ failure. Stimuli from non-infectious distress such as burns, trauma, pancreatitis, drug use and inhalation of toxic vapors can trigger a cytokine storm. The natural power and intervention of curcumin in suppressing the cytokine release are phenomenal.

Finally, turmeric curcumin bioavailability is vital. The supplement brand Bioperine contains piperine that increases utilization of the medicine in the body. Turmeric curcumin paves the way for the development of vaccines against the threat of Ebola virus diseases and other infectious disease.

By: Janet Grace Ortigas

Resources:

CNN: NIH: Ebola vaccine to be tested in human trials soon

In Vivo IIAR Journal: Curcumin Suppression of Cytokine Release and Cytokine Storm. A Potential Therapy for Patients with Ebola and Other Severe Viral Infections

Image Credit: Photo Courtesy of Marina Boyarkina – Public Domain License

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