Aging Successfully Reversed in Mice; Human Trials to Begin Next


Scientists have successfully reversed the aging process in mice according to a new study just released. Human trials are to begin next, possibly before the year is over. The study was published in the peer reviewed science journal Cell after researchers from both the U.S and Australia made the breakthrough discovery. Lead researcher David Sinclair of the University of New South Wales says he is hopeful that the outcome can be reproduced in human trials. A successful result in people would mean not just a slowing down of aging but a measurable reversal.

The study showed that after administering a certain compound to the mice, muscle degeneration and diseases caused by aging were reversed. Sinclair says the study results exceeded his expectations, explaining:

I’ve been studying aging at the molecular level now for nearly 20 years and I didn’t think I’d see a day when ageing could be reversed. I thought we’d be lucky to slow it down a little bit. The mice had more energy, their muscles were as though they’d be exercising and it was able to mimic the benefits of diet and exercise just within a week. We think that should be able to keep people healthier for longer and keep them from getting diseases of ageing.

The compound the mice ate resulted in their muscles becoming very toned, as if they’d been exercising. Inflammation, a key factor in many disease processes, was drastically reduced. Insulin resistance also declined dramatically and the mice had much more energy overall. Researchers say that what happened to the mice could be compared to a 60 year old person suddenly having the muscle tone and energy of someone in his or her 20s.

What’s more, say the researchers, these stunning results were realized within just one week’s time. The compound raises the level of a naturally occurring substance in the human body called nicotinamide adenine dinucleotide. This substance decreases as people age, although those who follow a healthy diet and get plenty of exercise do not suffer the same level of reduction in the substance as do people who do not exercise. This may explain why people who remain fit into their senior years often enjoy better health than others.

Scientists who participated in the study say that poor communication between mitochondria and the cell nucleus is to blame for the aging process. The compound the researchers have developed cause the cells to be able to “talk” to each other again. They compared the relationship between the nucleus and the mitochondria to a married couple; by the time the couple has been married for 20 years, “communication breaks down” and they don’t talk to each other as much. Just like a marriage, this relationship and communication within it can be repaired, say the researchers.

Aging has successfully been reversed in mice, but Sinclair says he needs to raise more money before he can commit to a date when trials may begin in humans. The results of this initial study in mice are very promising and may pave the way for similar results in humans.

By: Rebecca Savastio


ABC News

Science Direct

Huffington Post

75 Responses to "Aging Successfully Reversed in Mice; Human Trials to Begin Next"

  1. Jim page   August 30, 2015 at 2:20 pm

    Where do I sign?

  2. helga   March 12, 2015 at 1:00 pm

    I’d like to see more emphasis on NAD+ being utilized medically for tissue rejuvenation on patients effected with autoimmune and other illnesses.

  3. mike   December 20, 2014 at 10:13 pm

    I’ve no doubt a lot of people would say no, preferring to age naturally. I’d take it and reject aging.

  4. Tony Wallace   November 5, 2014 at 11:36 am

    Life Extension Magazine Nov ’14 has an article on NAD+’s DNA repair mechanism. Indicates studies on this started in 2001.

  5. Marti   November 5, 2014 at 10:47 am

    If it really worked for humans, we’d be looking at a serious overcrowding problem
    in the future.

  6. Bob   November 5, 2014 at 8:17 am

    “Just” regaining the muscle tone of a 30-year-old would be fantastic when you’re in your 70’s — even when you’re otherwise healthy and in good shape for your age. Getting up the hill from the supermarket, reducing the risk of falling and being able to get up if you do, seeing the better toned body in the mirror would all greatly improve ones quality of life.

  7. tepes   November 4, 2014 at 1:44 pm

    it will be expensive as hell , and only for the elite !

  8. CaitSidhe   April 5, 2014 at 8:09 pm

    *cough*Resident Evil*cough*

  9. gayle63   April 4, 2014 at 7:25 am

    I have heard of this study before, but I wonder if it would also reverse degenerative disease, especially brain degeneration (dementia, Alzheimer’s etc.). Just having toned muscle alone isn’t reversing ageing. What about bone health, heart health (although I suppose that is a muscle). Very, very interesting, but I suspect that this, like the Draco antiviral that popped up a few years ago, will mysteriously vanish from the radar.

    • DMT-07   November 5, 2014 at 10:46 am

      Muscle regeneration is just the proof-of-concept, probably selected by the researchers because performance deltas are easily measured. How do you tell that someone’s spleen is working better? More expensive testing. But even an undergrad can measure how long it takes a mouse to climb a vertical maze (a task both physically and cognitively challenging).
      As for expensive…sure, the wealthy will get it first, but they got DNA sequencing first (circa 2006, I believe.) But now you don’t have to pay US$300,000 for it…eight years later, it’s now under US$1000. Sure it’s nice when you can sell products to the people who buy cars that cost more than houses, but it’s the “bottom of the pyramid” where you can make billions…because your Total Addressable Market is vast.
      The future is here…it’s just not evenly distributed. So live as healthy a lifestyle as you can now…and live long enough to reach “escape velocity.”

  10. WetVajWoman   April 1, 2014 at 1:35 pm

    Lol can’t take anything seriously when someone in the comments is calling themselves “bonerman”.

  11. oliver   April 1, 2014 at 2:31 am

    April fools?

  12. Hugh Culliton   March 31, 2014 at 5:18 pm

    As a 40ish man who’s is starting to feel time’s force pressing onto his soul, life extension sounds cool. But given that we’re 7 billion and rising on this poor rock, I do question the necessity of the technology. Perhaps life extension should be reserved for colonists bound for new worlds

    • charles   April 8, 2014 at 3:56 pm

      There is a simple solution to this problem. Preform a vasectomy and Tubal ligation on anyone who wants the anti aging pill. This would hold the population steady.

      Also living indefinitely does not mean a person will live indefinitely. Due to accidents the average age was predicted to become 650.

      Finally with people living forever humans technology and society will progress faster. Imagine if Steven Jobs, Einstein, Leonardo Da Vinci, Thomas Edison, and Alan Turing were still alive what they could accomplish would be amazing.

      Finally it would improve the economy. People are educated for about 20 years (negative impact on the economy) then they work for 40-50 years (positive impact on the economy). By increase the working stage of people the economy would become stronger.

      Finally the earth has a current carrying capacity of 9-10 billion people. This number could also be largely increased by GMO crops, vegetarian diets, and renewable energy..

      While living forever is not for everyone. The choice should be made available because the benefits outweigh the costs.

  13. Alexander   March 31, 2014 at 1:02 pm

    Quite excited for the outcome of the tests. What I wonder is since it’s “reversing” aging, will it eventually stop? Or will you keep de-aging until you die of youth… Odd to think about, but I hope that issues gets resolved!

    • jabber wolf   March 31, 2014 at 3:28 pm

      I have been told this substance can start mitochondrial communication in even reverse dying cells. This was more for harvesting organs and preventing them from going bad or have the “dead signal” continue and desegregate the transplant.
      Then again, this will obviously be the reason for the impending zombie apocalypse as it reanimates dead tissue 😮

  14. howiemande   March 31, 2014 at 10:11 am

    we need love of life before longevity. as a race, war and killing expectations of core values deteriate our involvement of society and conversative abilities of life and long love.

  15. Maia Martucci   March 31, 2014 at 10:10 am

    So we can reverse aging, but we still can’t figure out a better, efficient, more sustainable source of energy than fossil fuels? Good job, humans.

    • charles   April 8, 2014 at 3:59 pm

      Do you use alternative energy?

      People are always complaining that we don’t have more sustainable sources of energy however they fail to go out of their way and invest in them. Instead they simply use the convenience of fossil fuels.

      Also fusion power is making huge strides. When that is complete (25-50 years) earth will have a source of unlimited (few million years worth), completely green, and cheap energy.

  16. max   March 31, 2014 at 10:04 am

    Sign me up for the trials, lol.

  17. Darva Earnest   March 31, 2014 at 9:10 am

    So if this is for real and restores collagen production in the body so that degeneration and wrinkles stop, I want in on it. By the way the Lord Jesus will restore His believing children with His divine health. He renews my youth as the wings of the eagles and my strength as the eagles. Oh I’m not Seth Earnest, I am his 54 yr old mom, Darva Earnest

    • Brian   March 31, 2014 at 9:30 am

      Don’t make this a religion thing, it’s not.

      • Benji   March 31, 2014 at 10:20 am

        Cell is peer-reviewed. The Bible wasn’t.
        I’m going to defer to peer-reviewing on this one.

      • Helena   March 31, 2014 at 10:22 am

        Actually…it very well COULD be a religious thing as the bible talks about Christ’s return happening after the life code is broken (essentially)…if we “stop people from dying…” wow…

        • Gavin   March 31, 2014 at 10:53 am

          Except the bible is a fictional book.

        • Poopster   March 31, 2014 at 12:58 pm

          Please stop. Go be excited about your 1800 year old fairy tale book some where else.

          • john   March 31, 2014 at 6:24 pm

            There are ethical and social questions, which are informed by religious ideas. Shooting forward with little thought about the affects, except for the typically myopic techno crowd wowed at a new toy, is a model for potentially bad things blind siding us. Of course, given the comments above in this thread, I’m wasting bandwidth. Far to sure of your correctness to think there might be a problem.

          • charles   April 8, 2014 at 4:02 pm

            Religion has caused enough problems and delayed human progress too much.

            We should be questioning the ethical and social legitimacy of organized religion not science that will help humans not only enjoy a better quality of life but also advance as a species.

    • BONERMAN   March 31, 2014 at 11:00 am


      • charles   April 8, 2014 at 4:03 pm

        Exactly! No one is forced to take this pill. If you want to die and go to your heaven no one is stopping you.

  18. FUe   March 31, 2014 at 8:46 am

    These trials still don’t prove to extend your lifespan. People going crazy over this, thinking it’s the ‘fountain of youth’ couldn’t be more wrong. Aging is a natural process, your body degrades over time and you eventually die. I honestly can’t wait to see this fail so I can sit back and laugh at the pathetic tossers who also believed the world was going to end because of an incomplete calendar.

    • Clayton   March 31, 2014 at 9:04 am

      Have you read the paper? Do you have access to the data, or are you simply deciding it can’t be real? If you do have access to the paper I’d love to see it. They’ve clearly done their research, and it’s not even comparable to the Mayan Calendar fiasco. Just because something is natural doesn’t mean it can’t be altered. Why does this one have to fail? The explanation given in the article states that the mitochondria doesn’t communicate well with the nucleus… which is very reasonable. The theory of endosymbiosis says that some early prokaryote created a relationship with the [once free living] mitochondrial ancestor.

      Do you have any actual evidence for your doubt, or have you just decided you’re all knowing?

    • apmechev   March 31, 2014 at 9:31 am

      Smallpox is a natural process too, but I’d rather it be exterminated.

      • deemster   March 31, 2014 at 10:23 am

        Where does smallpox come to play in all this?

  19. Justin   March 31, 2014 at 8:24 am

    Not fake, check the sources. If you dig deep enough you’ll find its true and reliable…
    Also saying “gay” to something you think is fake or stupid makes you very ignorant…

  20. Kevin Baconator   March 31, 2014 at 6:20 am

    Hey EB – you mad bro?

  21. Kyle   March 31, 2014 at 6:13 am

    April fool! =)

  22. John Price   March 31, 2014 at 6:12 am

    I would have expected this on April Fools Day . Are you sure its not printed early?

    • Gavin   March 31, 2014 at 10:56 am

      He has posted similar findings before. Someone ended up writing an article that looked like his work wasn’t actual true but now he has shown that it is. This is the real deal.

  23. Old woman   March 31, 2014 at 5:34 am

    I want to marry a 30 year old when I turn 200

  24. Paul Hart   March 31, 2014 at 5:02 am

    The poorest of people will be given this to extend their misery.

  25. Kalle   March 31, 2014 at 4:38 am

    Yeah it’s called steroids.

  26. sjaudey   March 31, 2014 at 4:01 am

    My generation is going to have the best looking corpses around

  27. marialavithi   March 31, 2014 at 3:45 am

    where do i signed up for human trials?

  28. bob   March 31, 2014 at 2:28 am

    well michale, get rich before then!

  29. Satan   March 31, 2014 at 1:31 am

    Yeah wow. This will destroy the planet if it actually works in humans… Everybody lives longer and their kids do etc..

    • Ohgodwhy   March 31, 2014 at 2:39 am

      I find it hilarious that Satan took the time to reply to this..

      • Vess   March 31, 2014 at 4:21 am

        Well You know .. Some things are just importand 🙂

      • Nadoddr   March 31, 2014 at 2:41 pm

        Well he’s not getting any souls if we stop dying.

        • ES   April 2, 2014 at 11:19 pm

          Ah, you would think that, but Satan works in mysterious ways right? He’s simply looking to the future. If people stop dying today, then the human population will sky rocket exponentially over the next few centuries, like it never has before. And when it simply gets too much for us to cope with and sustain ourselves, and a cataclysmic war breaks out, then he cashes in on the jackpot getting far more than he ever could have normally in the same amount of time.

          • charles   April 8, 2014 at 4:04 pm

            If you don’t want to live forever then don’t take the pill. However that being said crazy religious fanatics are not going to stand in the way of my future.

    • Not Satan   March 31, 2014 at 4:30 am

      Then we colonize

  30. HB   March 30, 2014 at 11:52 pm

    Why do articles concerning science have to be written by people that have no understanding of biochemistry?
    The author has no clue as to what the main purpose of NAD+ in a cell is and gives a horrible explanation as to how it “reverses” the aging process…
    Geez they could have a 9th grader in a basic biology course explain this better.

    • JB   March 31, 2014 at 2:21 am

      Because they’re journalists, not biologists, you pretentious jerk. They can’t be specialists in EVERY single industry, yet are required to break down a story into the most basic of premises in the quickest most digestible fashion for people who are similarly laymen for the most part. If you want a richer explanation of what’s going on here, subscribe to Cell.

      • EB   March 31, 2014 at 4:54 am

        A great writer once said “write about what you know”…this concept is lost in journalism and pretentious jerks calling people pretentious jerks.

        • Purple Headed Snakers   March 31, 2014 at 8:38 am

          That great writer probably believed in context as well; he was referring to creative writing, not journalism.

        • JB   March 31, 2014 at 6:29 pm

          You don’t realize how ironically dumb you sound. Try spend a day in the life of a journalist and better appreciate the demands of their industry before you jump to your conclusions.

          Rather than add nothing but negativity to the discussion, you might want to try simply be informative – as is clear, no one cares about your opinion, given how unreasonable a person you clearly are – but if you’re able to better inform us, please do.

  31. wallamazoo   March 30, 2014 at 8:32 am

    So I see they’ve discovered the Philosopher’s Stone finally.

    • Valchrist1313   March 31, 2014 at 12:57 pm

      I believe that may well what they’ve found, in which case this is just rediscovering an ancient secret. However, the dangers of longevity are the least of our concerns, if that is the case.

      The spice must flow.

  32. deromkring   March 30, 2014 at 8:29 am

    Where do i sign up for human trials?

  33. aaronmhamilton   March 29, 2014 at 11:50 am

    Michael Fay: hate to burst your resentment bubble, but the only reason this is going to be profitable is if most people indulge in it.

  34. Solomon   March 29, 2014 at 5:32 am


  35. kelle35Bengt   February 11, 2014 at 3:22 pm

    så bra då blir det bara rika och friska människor kvar på jorden hehe :O)

  36. bhatmahesht   February 10, 2014 at 8:51 pm

    I was expecting this to happen around 2035 with the advancement of transmission. However it seems the cell research coupled with artificial intelligence is pushing it before 2025 it seems.

    • LordHufflebutt   March 31, 2014 at 4:14 am

      It seems so.

  37. jesss   January 29, 2014 at 5:48 pm

    who will be the lucky people who get the anti aging trick tried on them? I VOLUNTEER AS TRIBUTEE!

  38. Stephen Cashman   January 29, 2014 at 3:19 pm

    The rich are testing it for the rest of us, ironing out all the bugs!

    • Punster   March 31, 2014 at 3:16 am

      And all the wrinkles

  39. Michael Fay   January 29, 2014 at 10:39 am

    If this comes to be it will be a revolutionary breakthrough, too bad the rich and elite will have access to it long before anyone else does.


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